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首页> European journal of medicinal chemistry> Hydrogen peroxide activated quinone methide precursors with enhanced DNA cross-linking capability and cytotoxicity towards cancer cells.

Hydrogen peroxide activated quinone methide precursors with enhanced DNA cross-linking capability and cytotoxicity towards cancer cells.

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作者： Yibin,Wang ^[1] ; Heli,Fan ^[1] ; Kumudha,Balakrishnan ^[2] ; Zechao,Lin ^[1] ; Sheng,Cao ^[1] ; Wenbing,Chen ^[1] ; Yukai,Fan ^[1] ; Quibria A,Guthrie ^[1] ; Huabing,Sun ^[1] ; Kelly A,Teske ^[1] ; Varsha,Gandhi ^[2] ; Leggy A,Arnold ^[1] ; Xiaohua,Peng ^[3]

作者单位： Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, WI, 53211, USA. ^[1] Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA. ^[2] Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, WI, 53211, USA. Electronic address: pengx@uwm.edu. ^[3]

关键词 Anticancer activity Arylboronates DNA interstrand cross-linking agents Hydrogen peroxide activation Quinone methide

主题词抗肿瘤药(Antineoplastic Agents);碱基序列(Base Sequence);苯衍生物(Benzene Derivatives);硼酸化物(Boronic Acids);细胞系, 肿瘤(Cell Line, Tumor);DNA(DNA);人类(Humans);过氧化氢(Hydrogen Peroxide);吲哚醌类(Indolequinones);嵌入剂(Intercalating Agents);肿瘤(Neoplasms)

DOI 10.1016/j.ejmech.2017.03.041

PMID 28388522

发布时间 2018-11-13

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European journal of medicinal chemistry

197-207页

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