Targeting Energy Metabolism in <i>Mycobacterium tuberculosis</i>, a New Paradigm in Antimycobacterial Drug Discovery.

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作者： Dirk,Bald ^[1] ; Cristina,Villellas ^[2] ; Ping,Lu ^[3] ; Anil,Koul ^[4]

作者单位： Department of Molecular Cell Biology, AIMMS, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands d.bald@vu.nl akoul@its.jnj.com. ^[1] Infectious Diseases and Vaccines Therapeutic Area, Janssen Research & Development, Beerse, Belgium. ^[2] Department of Molecular Cell Biology, AIMMS, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. ^[3] Infectious Diseases and Vaccines Therapeutic Area, Janssen Research & Development, Beerse, Belgium d.bald@vu.nl akoul@its.jnj.com. ^[4]

关键词 Mycobacterium tuberculosis antibiotics energy metabolism oxidative phosphorylation

主题词抗结核药(Antitubercular Agents);药物发现(Drug Discovery);能量代谢(Energy Metabolism);结核分枝杆菌(Mycobacterium tuberculosis);氧化磷酸化(Oxidative Phosphorylation)

DOI 10.1128/mBio.00272-17

PMID 28400527

发布时间 2019-12-27

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