N-Terminus Binding Preference for Either Tanshinone or Analogue in Both Inhibition of Amyloid Aggregation and Disaggregation of Preformed Amyloid Fibrils-Toward Introducing a Kind of Novel Anti-Alzheimer Compounds.

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作者： Mingyan,Dong ^[1] ; Wei,Zhao ^[1] ; Dingkun,Hu ^[1] ; Hongqi,Ai ^[1] ; Baotao,Kang ^[1]

作者单位： Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan , Jinan 250022, China. ^[1]

关键词 Alzheimer’s disease Aβ disaggregation/inhibition mechanism preferential binding at N-terminus region tanshinone

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);结合部位(Binding Sites);氢键合(Hydrogen Bonding);分子动力学模拟(Molecular Dynamics Simulation);神经保护药(Neuroprotective Agents);肽碎片(Peptide Fragments);蛋白质折叠(Protein Folding);蛋白质多聚化(Protein Multimerization);蛋白质稳定性(Protein Stability)

DOI 10.1021/acschemneuro.7b00080

PMID 28406293

发布时间 2019-12-10

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ACS chemical neuroscience

2017年8卷7期

1577-1588页

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N-Terminus Binding Preference for Either Tanshinone or Analogue in Both Inhibition of Amyloid Aggregation and Disaggregation of Preformed Amyloid Fibrils-Toward Introducing a Kind of Novel Anti-Alzheimer Compounds.

ACS chemical neuroscience

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ACS chemical neuroscience

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N-Terminus Binding Preference for Either Tanshinone or Analogue in Both Inhibition of Amyloid Aggregation and Disaggregation of Preformed Amyloid Fibrils-Toward Introducing a Kind of Novel Anti-Alzheimer Compounds.

ACS chemical neuroscience

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ACS chemical neuroscience

相关期刊

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