New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1.

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作者： Maria I,Kharitonova ^[1] ; Alexandra O,Denisova ^[2] ; Valeria L,Andronova ^[3] ; Alexei L,Kayushin ^[2] ; Irina D,Konstantinova ^[2] ; Svetlana K,Kotovskaya ^[4] ; Georgiy A,Galegov ^[3] ; Valery N,Charushin ^[4] ; Anatoly I,Miroshnikov ^[2]

作者单位： Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russian Federation. Electronic address: kharitonova-mari@rambler.ru. ^[1] Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russian Federation. ^[2] Federal State Budgetary Institution "Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya" of the Ministry of Health of the Russian Federation (D.I. Ivanovsky Institute of Virology), Gamaleya St. 18, Moscow 123098, Russian Federation. ^[3] Postovsky Institute of Organic Synthesis, The Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya/Academicheskaya St. 22/20, 620041 Ekaterinburg, Russian Federation; Ural Federal University named after the first President of Russia B. N. Yeltsin, Mira St. 19, 620002 Ekaterinburg, Russian Federation. ^[4]

关键词 Antiviral activity Benzimidazoles Fluorinated compounds Nucleoside phosphorylases Nucleosides Transglycosylation reaction