A Dose-finding and Biomarker Evaluation Phase Ib Study of Everolimus in Association With 5-Fluorouracil and Pelvic Radiotherapy as Neoadjuvant Treatment of Locally Advanced Rectal Cancer (E-LARC Study).

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作者： Fabio,Gelsomino ^[1] ; Federica,Bertolini ^[2] ; Gabriele,Luppi ^[2] ; Andrea,Spallanzani ^[2] ; Elisa,Pettorelli ^[2] ; Luca,Reggiani Bonetti ^[3] ; Bruno,Meduri ^[4] ; Gianrocco,Manco ^[5] ; Pierfranco,Conte ^[6] ; Stefano,Cascinu ^[2]

作者单位： Division of Oncology, Department of Oncology and Haematology, University Hospital of Modena, Modena, Italy. Electronic address: fabiogelsomino83@yahoo.it. ^[1] Division of Oncology, Department of Oncology and Haematology, University Hospital of Modena, Modena, Italy. ^[2] Pathology Unit, Department of Diagnostic Medicine and Public Health, University Hospital of Modena, Modena, Italy. ^[3] Division of Radiotherapy, Department of Oncology and Haematology, University Hospital of Modena, Modena, Italy. ^[4] Department of Surgical, Medical, Dental, and Morphological Sciences With Interest in Transplant, Oncological and Regenerative Medicine, University Hospital of Modena, Modena, Italy. ^[5] Division of Medical Oncology 2, Istituto Oncologico Veneto Istituto di Ricovero e Cura a Carattere Scientifico, Padua, Italy. ^[6]

关键词 Multimodal treatment NAR score Predictive biomarkers Target therapies Toxicities