首页> Journal of medicinal chemistry> Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.

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第一作者： Nicolas,Desroy

第一单位： Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France.

作者： Nicolas,Desroy ^[1] ; Christopher,Housseman ^[1] ; Xavier,Bock ^[1] ; Agnès,Joncour ^[1] ; Natacha,Bienvenu ^[1] ; Laëtitia,Cherel ^[1] ; Virginie,Labeguere ^[1] ; Emilie,Rondet ^[1] ; Christophe,Peixoto ^[1] ; Jean-Marie,Grassot ^[1] ; Olivier,Picolet ^[1] ; Denis,Annoot ^[1] ; Nicolas,Triballeau ^[1] ; Alain,Monjardet ^[1] ; Emanuelle,Wakselman ^[1] ; Veronique,Roncoroni ^[1] ; Sandrine,Le Tallec ^[1] ; Roland,Blanque ^[1] ; Celine,Cottereaux ^[1] ; Nele,Vandervoort ^[2] ; Thierry,Christophe ^[2] ; Patrick,Mollat ^[1] ; Marieke,Lamers ^[3] ; Marielle,Auberval ^[1] ; Boska,Hrvacic ^[4] ; Jovica,Ralic ^[4] ; Line,Oste ^[2] ; Ellen,van der Aar ^[2] ; Reginald,Brys ^[2] ; Bertrand,Heckmann ^[1]

作者单位： Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France. ^[1] Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium. ^[2] Charles River Laboratories , Chesterford Research Park, CB10 1XL Saffron Walden, United Kingdom. ^[3] Fidelta Ltd. , Prilaz baruna Filipovića 29, Zagreb, HR-10000, Croatia. ^[4]