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首页> Oncotarget> Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport.

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport.

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作者： Raghavendra,Gowda ^[1] ; Gajanan S,Inamdar ^[2] ; Omer,Kuzu ^[3] ; Saketh S,Dinavahi ^[4] ; Jacek,Krzeminski ^[1] ; Madhu Babu,Battu ^[1] ; Sreedhara R,Voleti ^[1] ; Shantu,Amin ^[1] ; Gavin P,Robertson ^[5]

作者单位： Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[1] The Penn State Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[2] Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[3] Foreman Foundation for Melanoma Research Laboratory, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[4] Drug Discovery Research Laboratory, INDRAS Private Limited, Hyderabad, India 500040. ^[5] Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[6] Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[7] Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ^[8]

关键词 AKT abietic acid leelamine melanoma structure-activity relationship

主题词动物(Animals);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);自噬(Autophagy);生物转运(Biological Transport);细胞存活(Cell Survival);胆固醇(Cholesterol);剂量效应关系, 药物(Dose-Response Relationship, Drug);胞吞作用(Endocytosis);人类(Humans);黑色素瘤(Melanoma);分子构象(Molecular Conformation);分子动力学模拟(Molecular Dynamics Simulation);分子结构(Molecular Structure);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship)

DOI 10.18632/oncotarget.16002

PMID 28423677

发布时间 2019-12-10

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Oncotarget

Oncotarget

2017年8卷17期

28260-28277页

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