Simian Immunodeficiency Virus Targeting of CXCR3<sup>+</sup> CD4<sup>+</sup> T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets.

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作者： Masayuki,Fujino ^[1] ; Hirotaka,Sato ^[1] ; Tomotaka,Okamura ^[2] ; Akihiko,Uda ^[2] ; Satoshi,Takeda ^[3] ; Nursarat,Ahmed ^[1] ; Shigeyuki,Shichino ^[1] ; Teiichiro,Shiino ^[2] ; Yohei,Saito ^[4] ; Satoru,Watanabe ^[5] ; Chie,Sugimoto ^[1] ; Marcelo J,Kuroda ^[2] ; Manabu,Ato ^[1] ; Yoshiyuki,Nagai ^[2] ; Shuji,Izumo ^[6] ; Kouji,Matsushima ^[6] ; Masaaki,Miyazawa ^[7] ; Aftab A,Ansari ^[8] ; Francois,Villinger ^[9] ; Kazuyasu,Mori ^[4]

作者单位： AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan. ^[1] Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Ibaraki, Japan. ^[2] Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan. ^[3] Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ^[4] Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan. ^[5] Division of Immunology, Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA. ^[6] Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan. ^[7] Center of Research Network for Infectious Diseases, Riken, Tokyo, Japan. ^[8] Molecular Pathology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. ^[9] Department of Immunology, Kindai University School of Medicine, Osaka-Sayama, Osaka, Japan. ^[10] Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA. ^[11] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. ^[12] AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan mori@nih.go.jp. ^[13]

关键词 CD4+ T cell CXCL10 CXCR3 SIV Th1 glycosylation innate immunity macrophages monocytes pathogenesis