T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model.

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作者： Kun,Wang ^[1] ; Yanlin,Li ^[1] ; Rui,Han ^[2] ; Guofeng,Cai ^[1] ; Chuan,He ^[1] ; Guoliang,Wang ^[1] ; Di,Jia ^[1]

作者单位： Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. ^[1] Department of Diabetology, First Affiliated Hospital of Kunming Medical University, Kunming, China. ^[2]

主题词软骨蛋白聚糖类(Aggrecans);动物(Animals);软骨, 关节(Cartilage, Articular);趋化因子CXCL12(Chemokine CXCL12);胶原Ⅱ型(Collagen Type II);疾病模型, 动物(Disease Models, Animal);减量调节(Down-Regulation);豚鼠(Guinea Pigs);人类(Humans);男(雄)性(Male);基质金属蛋白酶类(Matrix Metalloproteinases);寡肽类(Oligopeptides);骨关节炎(Osteoarthritis);信号传导(Signal Transduction)

DOI 10.1371/journal.pone.0176048

PMID 28426786

发布时间 2018-12-21

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2017年12卷4期

e0176048页

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T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model.

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T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model.

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