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Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.

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第一作者： Haoyang,Zhang

第一单位： College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.

作者： Haoyang,Zhang ^[1] ; Wenkui,Wu ^[1] ; Chao,Feng ^[2] ; Zhaogang,Liu ^[2] ; Enhe,Bai ^[3] ; Xueyuan,Wang ^[1] ; Meng,Lei ^[3] ; Hao,Cheng ^[2] ; Huayun,Feng ^[3] ; Jingmiao,Shi ^[2] ; Jia,Wang ^[2] ; Zhao,Zhang ^[1] ; Tao,Jin ^[1] ; Shanshan,Chen ^[2] ; Shihe,Hu ^[4] ; Yongqiang,Zhu ^[5]

作者单位： College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China. ^[1] Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China. ^[2] College of Science, Nanjing Forestry University, No. 159 Longpan Road, Nanjing 210037, PR China. ^[3] Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China. Electronic address: hsh.2@163.com. ^[4] College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China. Electronic address: zhyqscu@hotmail.com. ^[5]

关键词 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline derivatives EGFR modulator L858R/T790M double mutants Non-small cell lung cancer