The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.

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作者： Chun-Shik,Shin ^[1] ; Prashant,Mishra ^[1] ; Jeramie D,Watrous ^[2] ; Valerio,Carelli ^[3] ; Marilena,D'Aurelio ^[4] ; Mohit,Jain ^[5] ; David C,Chan ^[6]

作者单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA. ^[1] Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8502, USA. ^[2] Department of Medicine and Pharmacology, University of California, La Jolla, San Diego, California 92093, USA. ^[3] IRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Via Altura 3, 40139 Bologna, Italy. ^[4] Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Via Altura 3, 40139 Bologna, Italy. ^[5] Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue, A501, New York, New York 10065, USA. ^[6]

主题词氨基酸转运系统y+(Amino Acid Transport System y+);抗氧化剂(Antioxidants);生物转运(Biological Transport);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);培养基(Culture Media);胱氨酸(Cystine);上皮细胞(Epithelial Cells);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);葡萄糖(Glucose);谷氨酸(Glutamic Acid);谷氨酰胺(Glutamine);HEK293细胞(HEK293 Cells);人类(Humans);线粒体(Mitochondria);NF-E2相关因子2(NF-E2-Related Factor 2);氧化磷酸化(Oxidative Phosphorylation);信号传导(Signal Transduction)

DOI 10.1038/ncomms15074

PMID 28429737

发布时间 2021-01-03

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Nature communications

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The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.

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The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.

Nature communications

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