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Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

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第一作者： Grietje,Krabbe

第一单位： Gladstone Institute of Neurological Diseases, University of California, San Francisco, CA 94158.;Department of Neurology, University of California, San Francisco, CA 94158.

作者： Grietje,Krabbe ^[1] ; S Sakura,Minami ^[1] ; Jon I,Etchegaray ^[1] ; Praveen,Taneja ^[2] ; Biljana,Djukic ^[2] ; Dimitrios,Davalos ^[2] ; David,Le ^[2] ; Iris,Lo ^[2] ; Lihong,Zhan ^[1] ; Meredith C,Reichert ^[1] ; Faten,Sayed ^[3] ; Mario,Merlini ^[2] ; Michael E,Ward ^[1] ; David C,Perry ^[4] ; Suzee E,Lee ^[4] ; Ana,Sias ^[4] ; Christopher N,Parkhurst ^[5] ; Wen-Biao,Gan ^[5] ; Katerina,Akassoglou ^[1] ; Bruce L,Miller ^[4] ; Robert V,Farese ^[6] ; Li,Gan ^[7]

作者单位： Gladstone Institute of Neurological Diseases, University of California, San Francisco, CA 94158.;Department of Neurology, University of California, San Francisco, CA 94158. ^[1] Gladstone Institute of Neurological Diseases, University of California, San Francisco, CA 94158. ^[2] Neuroscience Graduate Program, University of California, San Francisco, CA 94158. ^[3] Department of Neurology, University of California, San Francisco, CA 94158.;Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158. ^[4] Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016. ^[5] Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.;Department of Cell Biology, Harvard Medical School, Boston, MA 02115. ^[6] Gladstone Institute of Neurological Diseases, University of California, San Francisco, CA 94158; lgan@gladstone.ucsf.edu.;Department of Neurology, University of California, San Francisco, CA 94158.;Neuroscience Graduate Program, University of California, San Francisco, CA 94158. ^[7]

关键词 FTD OCD TNF microglia progranulin