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Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example for In Silico Assessment of Adaptive Dosing Strategies.

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第一作者： Jessica,Wojciechowski

第一单位： Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, 5001, Australia. jessica.wojciechowski@mymail.unisa.edu.au.

作者： Jessica,Wojciechowski ^[1] ; Richard N,Upton ^[2] ; Diane R,Mould ^[3] ; Michael D,Wiese ^[4] ; David J R,Foster ^[5]

作者单位： Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, 5001, Australia. jessica.wojciechowski@mymail.unisa.edu.au. ^[1] Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, 5001, Australia.;Projections Research Inc., Phoenixville, Pennsylvania, USA. ^[2] Projections Research Inc., Phoenixville, Pennsylvania, USA. ^[3] School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia. ^[4] Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, 5001, Australia. ^[5]

关键词 Bayesian dosing infliximab pharmacokinetics pharmacometrics

医学主题词计算机模拟(Computer Simulation);剂量效应关系, 药物(Dose-Response Relationship, Drug);胃肠病用药(Gastrointestinal Agents);人类(Humans);炎性肠疾病(Inflammatory Bowel Diseases)

DOI 10.1208/s12248-017-0082-8

PMID 28444562

发布时间 2018-11-13

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