PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.-论文-万方医学网

作者： Berkley E,Gryder ^[1] ; Marielle E,Yohe ^[1] ; Hsien-Chao,Chou ^[2] ; Xiaohu,Zhang ^[1] ; Joana,Marques ^[3] ; Marco,Wachtel ^[4] ; Beat,Schaefer ^[4] ; Nirmalya,Sen ^[4] ; Young,Song ^[1] ; Alberto,Gualtieri ^[1] ; Silvia,Pomella ^[5] ; Rossella,Rota ^[5] ; Abigail,Cleveland ^[5] ; Xinyu,Wen ^[1] ; Sivasish,Sindiri ^[1] ; Jun S,Wei ^[1] ; Frederic G,Barr ^[1] ; Sudipto,Das ^[6] ; Thorkell,Andresson ^[7] ; Rajarshi,Guha ^[7] ; Madhu,Lal-Nag ^[3] ; Marc,Ferrer ^[3] ; Jack F,Shern ^[3] ; Keji,Zhao ^[1] ; Craig J,Thomas ^[2] ; Javed,Khan ^[8]

作者单位： Genetics Branch, NCI, NIH, Bethesda, Maryland. ^[1] Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. ^[2] Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, Maryland. ^[3] University Children's Hospital, Zurich, Switzerland. ^[4] Department of Oncohematology, Ospedale Pediatrico Bambino Gesù Research Institute, Rome, Italy. ^[5] Laboratory of Pathology, NCI, NIH, Bethesda, Maryland. ^[6] Laboratory of Proteomics and Analytical Technologies, Advanced Technologies Center, NCI, Frederick, Maryland. ^[7] Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland. ^[8] Genetics Branch, NCI, NIH, Bethesda, Maryland. khanjav@mail.nih.gov. ^[9]

主题词动物(Animals);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);染色质(Chromatin);增强子元件, 遗传学(Enhancer Elements, Genetic);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);人类(Humans);男(雄)性(Male);小鼠(Mice);肌D蛋白质(MyoD Protein);肌形成蛋白(Myogenin);核蛋白质类(Nuclear Proteins);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);成对盒转录因子类(Paired Box Transcription Factors);蛋白质结合(Protein Binding);横纹肌肉瘤, 腺泡状(Rhabdomyosarcoma, Alveolar);小分子化合物库(Small Molecule Libraries);转录因子(Transcription Factors);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/2159-8290.CD-16-1297

PMID 28446439

发布时间 2024-06-15

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PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.

Cancer discovery

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Cancer discovery

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PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.

Cancer discovery

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Cancer discovery

相关期刊

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