首页> The Journal of biological chemistry> CRISPR/Cas9-mediated gene knockout screens and target identification via whole-genome sequencing uncover host genes required for picornavirus infection.

CRISPR/Cas9-mediated gene knockout screens and target identification via whole-genome sequencing uncover host genes required for picornavirus infection.

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第一作者： Heon Seok,Kim

第一单位： From the Center for Genome Engineering, Institute for Basic Science, Seoul 151-747, South Korea.;the Department of Chemistry, Seoul National University, Seoul 151-747, South Korea.

作者： Heon Seok,Kim ^[1] ; Kyungjin,Lee ^[2] ; Sangsu,Bae ^[3] ; Jeongbin,Park ^[3] ; Chong-Kyo,Lee ^[2] ; Meehyein,Kim ^[4] ; Eunji,Kim ^[5] ; Minju,Kim ^[5] ; Seokjoong,Kim ^[5] ; Chonsaeng,Kim ^[6] ; Jin-Soo,Kim ^[7]

作者单位： From the Center for Genome Engineering, Institute for Basic Science, Seoul 151-747, South Korea.;the Department of Chemistry, Seoul National University, Seoul 151-747, South Korea. ^[1] the Center for Convergent Research of Emerging Virus Infection and. ^[2] the Department of Chemistry, Hanyang University, Seoul 04763, South Korea, and. ^[3] Virus Research and Testing Center, Korea Research Institute of Chemical Technology, Daejeon 34114, South Korea. ^[4] ToolGen, Inc., Byucksan Kyoungin Digital Valley 2-Cha, Geumcheon-Gu, Seoul 153-023, South Korea. ^[5] the Center for Convergent Research of Emerging Virus Infection and chonskim@krict.re.kr. ^[6] From the Center for Genome Engineering, Institute for Basic Science, Seoul 151-747, South Korea, jskim01@snu.ac.kr.;the Department of Chemistry, Seoul National University, Seoul 151-747, South Korea. ^[7]

关键词 CRISPR screen CRISPR/Cas Enterovirus D68 RNA virus host-pathogen interaction poliovirus sialic acid whole-genome sequencing

医学主题词基因敲低技术(Gene Knockdown Techniques);基因组, 人(Genome, Human);全基因组关联研究(Genome-Wide Association Study);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);脊髓灰质炎(Poliomyelitis);脊髓灰质炎病毒(Poliovirus)

DOI 10.1074/jbc.M117.782425

PMID 28446605

发布时间 2021-02-05

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