Post-spinal cord injury astrocyte-mediated functional recovery in rats after intraspinal injection of the recombinant adenoviral vectors Ad5-VEGF and Ad5-ANG.
作者:
关键词
ALS = amyotrophic lateral sclerosisANG = angiogeninANG1 = angiotensin-1AQP4 = aquaporin 4BBB = Basso, Beattie, and BresnahanCC = central canalCST = corticospinal tractDAPI = 4,6′-diamino-2-phenylindole-dihydrochlorideDREZ = dorsal root entry zoneGFAP = glial fibrillary acidic proteinGFP = green fluorescent proteinNG2 = chondroitin sulfate proteoglycan 4OLIG2 = oligodendrocyte transcription factor 2PBS = phosphate-buffered salinePFU = plaque-forming unitRT-PCR = real-time polymerase chain reactionSCI = spinal cord injuryVEGFVEGF = vascular endothelial growth factorVF = ventral funiculiVH = ventral hornsadenovirus vectorangiogeninastrocytedpi = days post injuryspinal cord injuryvascular endothelial growth factor
主题词
腺病毒科(Adenoviridae);动物(Animals);星形细胞(Astrocytes);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);遗传载体(Genetic Vectors);人类(Humans);注射, 脊髓(Injections, Spinal);男(雄)性(Male);运动活动(Motor Activity);RNA, 信使(RNA, Messenger);随机分配(Random Allocation);大鼠, Wistar(Rats, Wistar);功能恢复(Recovery of Function);核糖核酸酶, 胰腺(Ribonuclease, Pancreatic);脊髓(Spinal Cord);脊髓损伤(Spinal Cord Injuries);脊髓再生(Spinal Cord Regeneration);血管内皮生长因子A(Vascular Endothelial Growth Factor A)
DOI
10.3171/2016.9.SPINE15959
PMID
28452633
发布时间
2017-07-17
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Journal of neurosurgery. Spine
105-115页
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