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首页> Journal of photochemistry and photobiology. B, Biology> Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy.

Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy.

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作者： Maiara Camotti,Montanha ^[1] ; Larissa Lachi,Silva ^[1] ; Fernanda Belincanta Borghi,Pangoni ^[1] ; Gabriel Batista,Cesar ^[2] ; Renato Sonchini,Gonçalves ^[2] ; Wilker,Caetano ^[2] ; Noboru,Hioka ^[2] ; Tania Toyomi,Tominaga ^[3] ; Márcia Edilaine Lopes,Consolaro ^[4] ; Andréa,Diniz ^[1] ; Elza,Kimura ^[5]

作者单位： Department of Pharmacy, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. ^[1] Department of Chemistry, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. ^[2] Departament of Physics, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil. ^[3] Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. ^[4] Department of Pharmacy, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. Electronic address: ekimura@uem.br. ^[5]

关键词 Cytotoxicity activity Hypericin Intestinal bacteria Nanoencapsulation Photodynamic therapy Pluronics P123

主题词蒽类(Anthracenes);抗感染药(Anti-Infective Agents);Caco-2细胞(Caco-2 Cells);细胞存活(Cell Survival);结直肠肿瘤(Colorectal Neoplasms);药物调剂(Drug Compounding);屎肠球菌(Enterococcus faecium);大肠杆菌(Escherichia coli);HT29细胞(HT29 Cells);人类(Humans);光(Light);微胶粒(Micelles);二萘嵌苯(Perylene);光化学疗法(Photochemotherapy);光敏感药(Photosensitizing Agents);泊洛扎林(Poloxalene);金黄色葡萄球菌(Staphylococcus aureus);表面特性(Surface Properties)

DOI 10.1016/j.jphotobiol.2017.04.008

PMID 28454049

发布时间 2021-12-04

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Journal of photochemistry and photobiology. B, Biology

247-255页

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