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Gli1<sup>+</sup> Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

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第一作者： Rebekka K,Schneider

第一单位： Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: r.k.schneider@erasmusmc.nl.

作者： Rebekka K,Schneider ^[1] ; Ann,Mullally ^[2] ; Aurelien,Dugourd ^[3] ; Fabian,Peisker ^[4] ; Remco,Hoogenboezem ^[5] ; Paulina M H,Van Strien ^[5] ; Eric M,Bindels ^[5] ; Dirk,Heckl ^[6] ; Guntram,Büsche ^[7] ; David,Fleck ^[8] ; Gerhard,Müller-Newen ^[9] ; Janewit,Wongboonsin ^[10] ; Monica,Ventura Ferreira ^[11] ; Victor G,Puelles ^[4] ; Julio,Saez-Rodriguez ^[3] ; Benjamin L,Ebert ^[2] ; Benjamin D,Humphreys ^[12] ; Rafael,Kramann ^[13]

作者单位： Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: r.k.schneider@erasmusmc.nl. ^[1] Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. ^[2] Joint Research Centre for Computational Biomedicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany. ^[3] Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany. ^[4] Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands. ^[5] Division of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany. ^[6] Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany. ^[7] Department of Chemosensation, Institute of Biology II, RWTH Aachen University, 52074 Aachen, Germany. ^[8] Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52074 Aachen, Germany. ^[9] Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700 Bangkok, Thailand. ^[10] Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, 52074 Aachen, Germany. ^[11] Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. ^[12] Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: rkramann@gmx.net. ^[13]

关键词 Gli1 bone marrow fibrosis mesenchymal stem cells myelofibrosis myeloproliferative neoplasms