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Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming.

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第一作者： Arven,Saunders

第一单位： The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

作者： Arven,Saunders ^[1] ; Dan,Li ^[1] ; Francesco,Faiola ^[2] ; Xin,Huang ^[2] ; Miguel,Fidalgo ^[2] ; Diana,Guallar ^[2] ; Junjun,Ding ^[2] ; Fan,Yang ^[2] ; Yang,Xu ^[3] ; Hongwei,Zhou ^[2] ; Jianlong,Wang ^[4]

作者单位： The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[1] The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[2] Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. ^[3] The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jianlong.wang@mssm.edu. ^[4]

关键词 iPSC phospho-NANOG pluripotency post-translational modification reprogramming self-renewal serine to alanine mutation

医学主题词动物(Animals);细胞系(Cell Line);细胞, 培养的(Cells, Cultured);DAX-1孤儿核受体(DAX-1 Orphan Nuclear Receptor);DNA结合蛋白质类(DNA-Binding Proteins);胚胎干细胞(Embryonic Stem Cells);诱导多能干细胞(Induced Pluripotent Stem Cells);小鼠(Mice);突变, 误义(Mutation, Missense);八聚体转录因子3(Octamer Transcription Factor-3);磷酰化(Phosphorylation);蛋白质加工, 转译后(Protein Processing, Post-Translational);原癌基因蛋白质类(Proto-Oncogene Proteins);受体, 雌激素(Receptors, Estrogen);转录因子(Transcription Factors)

DOI 10.1016/j.stemcr.2017.03.023

PMID 28457890

发布时间 2018-11-13

基金项目

R01 GM095942/GM/NIGMS NIH HHS/United States R21 HD087722/HD/NICHD NIH HHS/United States T32 HD075735/HD/NICHD NIH HHS/United States

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Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming.

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