A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles.

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第一作者： Lydia R,Meador

第一单位： Ira A. Fulton School of Engineering, Arizona State University, Tempe, AZ, USA; Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA.

作者： Lydia R,Meador ^[1] ; Sarah A,Kessans ^[2] ; Jacquelyn,Kilbourne ^[3] ; Karen V,Kibler ^[3] ; Giuseppe,Pantaleo ^[4] ; Mariano Esteban,Roderiguez ^[5] ; Joseph N,Blattman ^[2] ; Bertram L,Jacobs ^[6] ; Tsafrir S,Mor ^[7]

作者单位： Ira A. Fulton School of Engineering, Arizona State University, Tempe, AZ, USA; Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA. ^[1] Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA. ^[2] Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA. ^[3] Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland; Swiss Vaccine Research Institute, Lausanne, Switzerland. ^[4] Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia - CSIC, Madrid, Spain. ^[5] Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA. Electronic address: bjacobs@asu.edu. ^[6] Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA. Electronic address: tsafrir.mor@asu.edu. ^[7]

关键词 Electron microscopy HIV-1 Live vector vaccines Prime/boost Subunit vaccines Tobacco mosaic virus Vaccinia virus Virus-like particles