Ivabradine attenuates the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice.

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第一作者： Katarzyna M,Sawicka

第一单位： Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.

作者： Katarzyna M,Sawicka ^[1] ; Katarzyna,Załuska ^[2] ; Agnieszka,Wawryniuk ^[3] ; Karolina,Załuska-Patel ^[2] ; Michał,Szczyrek ^[3] ; Bartłomiej,Drop ^[2] ; Jadwiga,Daniluk ^[3] ; Monika,Szpringer ^[4] ; Dorota,Żółkowska ^[5] ; Jarogniew J,Łuszczki ^[6]

作者单位： Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland. ^[1] Department of Pathophysiology, Medical University of Lublin, Lublin, Poland. ^[2] Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland. ^[3] Faculty of Medicine and Health Sciences, The Jan Kochanowski University in Kielce, Kielce, Poland. ^[4] Department of Neurology, School of Medicine, University of California-Davis, Sacramento, CA, USA. ^[5] Department of Pathophysiology, Medical University of Lublin, Lublin, Poland. Electronic address: jarogniew.luszczki@gmail.com. ^[6]

关键词 Antiepileptic drugs Ivabradine Maximal electroshock-induced seizures Pharmacokinetic/pharmacodynamic interaction