Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

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作者： Sigrid,Jall ^[1] ; Stephan,Sachs ^[2] ; Christoffer,Clemmensen ^[3] ; Brian,Finan ^[3] ; Frauke,Neff ^[4] ; Richard D,DiMarchi ^[5] ; Matthias H,Tschöp ^[3] ; Timo D,Müller ^[6] ; Susanna M,Hofmann ^[7]

作者单位： Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany. ^[1] Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany. ^[2] Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. ^[3] German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany. ^[4] Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. ^[5] Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address: timo.mueller@helmholtz-muenchen.de. ^[6] German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany. Electronic address: susanna.hofmann@helmholtz-muenchen.de. ^[7]

关键词 Diabetes Dyslipidemia Glucose homeostasis Obesity Pharmacotherapy Sex differences

主题词体脂肪率(Adiposity);动物(Animals);血脂异常(Dyslipidemias);进食(Eating);脂肪肝(Fatty Liver);女(雌)性(Female);肠抑胃肽(Gastric Inhibitory Polypeptide);胰高血糖素(Glucagon);胰高血糖素样肽1(Glucagon-Like Peptide 1);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);肥胖症(Obesity);性别因素(Sex Factors)

DOI 10.1016/j.molmet.2017.02.002

PMID 28462078

发布时间 2018-11-15

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Molecular metabolism

2017年6卷5期

440-446页

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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Molecular metabolism

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Molecular metabolism

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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Molecular metabolism

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Molecular metabolism

相关期刊

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