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首页> Bioorganic & medicinal chemistry> Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors.

Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors.

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作者： Xiaoyan,Han ^[1] ; Yifan,Zhong ^[1] ; Guan,Zhou ^[1] ; Hui,Qi ^[1] ; Shengbin,Li ^[1] ; Qiang,Ding ^[1] ; Zhenming,Liu ^[2] ; Yali,Song ^[3] ; Xiaoqiang,Qiao ^[4]

作者单位： Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China. ^[1] Drug Design Center, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. ^[2] Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China. Electronic address: yalisong@hbu.edu.cn. ^[3] Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China. Electronic address: xiaoqiao@hbu.edu.cn. ^[4]

关键词 Anticancer activity Molecular docking N-(carbobenzyloxy) derivatives Topoisomerase IIα inhibitor

主题词抗原, 肿瘤(Antigens, Neoplasm);抗肿瘤药(Antineoplastic Agents);天冬氨酸(Aspartic Acid);细胞系, 肿瘤(Cell Line, Tumor);DNA拓扑异构酶类, Ⅱ型(DNA Topoisomerases, Type II);DNA结合蛋白质类(DNA-Binding Proteins);人类(Humans);肿瘤(Neoplasms);苯丙氨酸(Phenylalanine);构效关系(Structure-Activity Relationship);拓扑异构酶II抑制剂(Topoisomerase II Inhibitors)

DOI 10.1016/j.bmc.2017.03.065

PMID 28462840

发布时间 2017-12-08

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Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

2017年25卷12期

3116-3126页

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