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Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE's STAT-Net.

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第一作者： Jean-François,Timsit

第一单位： UMR 1137 IAME Inserm/Université Paris Diderot, 75018, Paris, France. jean-francois.timsit@bch.aphp.fr.;APHP Medical and Infectious Diseases ICU, Bichat Hospital, 46 Rue Henri Huchard, 75018, Paris, France. jean-francois.timsit@bch.aphp.fr.

作者： Jean-François,Timsit ^[1] ; Marlieke E A,de Kraker ^[2] ; Harriet,Sommer ^[3] ; Emmanuel,Weiss ^[4] ; Esther,Bettiol ^[5] ; Martin,Wolkewitz ^[3] ; Stavros,Nikolakopoulos ^[6] ; David,Wilson ^[7] ; Stephan,Harbarth ^[5] ; COMBACTE-NET consortium

作者单位： UMR 1137 IAME Inserm/Université Paris Diderot, 75018, Paris, France. jean-francois.timsit@bch.aphp.fr.;APHP Medical and Infectious Diseases ICU, Bichat Hospital, 46 Rue Henri Huchard, 75018, Paris, France. jean-francois.timsit@bch.aphp.fr. ^[1] Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. marlieke.dekraker@hcuge.ch. ^[2] Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany. ^[3] Université Paris Diderot, 75018, Paris, France.;APHP Anesthesiology and Critical Care Department, Beaujon Hospital, Paris, France. ^[4] Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. ^[5] Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. ^[6] AstraZeneca, Macclesfield, SK10 4TG, UK. ^[7]

关键词 Antibiotic therapy Consensus Endpoints Randomized clinical trials Severe infections