Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.-论文-万方医学网

作者： Stefano,Benvegnù ^[1] ; María Inés,Mateo ^[2] ; Ernest,Palomer ^[2] ; Jerónimo,Jurado-Arjona ^[2] ; Carlos G,Dotti ^[3]

作者单位： Department of Molecular Neurobiology, Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Madrid 28049, Spain. Electronic address: sbenvegnu@cbm.csic.es. ^[1] Department of Molecular Neurobiology, Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Madrid 28049, Spain. ^[2] Department of Molecular Neurobiology, Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Madrid 28049, Spain. Electronic address: cdotti@cbm.csic.es. ^[3]

主题词转录激活因子3(Activating Transcription Factor 3);主动转运, 细胞核(Active Transport, Cell Nucleus);衰老(Aging);动物(Animals);行为, 动物(Behavior, Animal);细胞核(Cell Nucleus);细胞存活(Cell Survival);染色质(Chromatin);认知(Cognition);细胞质(Cytoplasm);HEK293细胞(HEK293 Cells);海马(Hippocampus);人类(Humans);迷宫学习(Maze Learning);小鼠, 近交C57BL(Mice, Inbred C57BL);神经元(Neurons);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);RNA干扰(RNA Interference);大鼠, Wistar(Rats, Wistar);信号传导(Signal Transduction);应激, 生理学(Stress, Physiological);转录, 遗传(Transcription, Genetic);转染(Transfection);泛素(Ubiquitin);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination)

DOI 10.1016/j.molcel.2017.04.005

PMID 28475871

发布时间 2017-09-06

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Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Molecular cell

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Molecular cell

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Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Molecular cell

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Molecular cell

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