Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington's disease human induced pluripotent stem cell (hiPSC) model.

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第一作者： Simona,Baronchelli

第一单位： Institute of Genetic and Biomedical Research, National Research Council (IRGB-CNR), via Fantoli 16/15, 20138 Milan, Italy.

作者： Simona,Baronchelli ^[1] ; Alberto,La Spada ^[1] ; Aikaterini,Ntai ^[2] ; Andrea,Barbieri ^[1] ; Paola,Conforti ^[3] ; Gloria Saccani,Jotti ^[4] ; Serena,Redaelli ^[5] ; Angela,Bentivegna ^[6] ; Pasquale,De Blasio ^[2] ; Ida,Biunno ^[7]

作者单位： Institute of Genetic and Biomedical Research, National Research Council (IRGB-CNR), via Fantoli 16/15, 20138 Milan, Italy. ^[1] Integrated Systems Engineering Srl, Via Fantoli 16/15, 20138 Milano, Italy. ^[2] Department of Biosciences, University of Milan and Istituto Nazionale di Genetica Molecolare Padiglione Invernizzi, Via Francesco Sforza 35, 20122 Milan, Italy. ^[3] Department of Biological Science, Biotechnology and Translational - S.Bi.Bi.T., University of Parma, Via Gramsci 14, 43121 Parma, Italy. ^[4] Department of Surgery and Translational Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Milan, Italy. ^[5] Department of Surgery and Translational Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Milan, Italy; NeuroMI, Milan Center of Neuroscience, via Pergolesi 33, 20900 Monza, Italy. ^[6] Institute of Genetic and Biomedical Research, National Research Council (IRGB-CNR), via Fantoli 16/15, 20138 Milan, Italy; IRCCS Multimedica, via Fantoli 16/15, 20138 Milano, Italy. Electronic address: ida.biunno@isenet.it. ^[7]

关键词 Chromatin remodeling DNA methylation Disease modifying genes Human induced pluripotent stem cells (hiPSCs)Huntington's disease