Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.

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作者： Michele,Tonelli ^[1] ; Lieve,Naesens ^[2] ; Sabrina,Gazzarrini ^[3] ; Matteo,Santucci ^[4] ; Elena,Cichero ^[5] ; Bruno,Tasso ^[5] ; Anna,Moroni ^[3] ; Maria Paola,Costi ^[4] ; Roberta,Loddo ^[6]

作者单位： Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, 16132 Genova, Italy. Electronic address: tonelli@difar.unige.it. ^[1] Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. ^[2] Department of Biosciences and National Research Council (CNR), Biophysics Institute (IBF), University of Milan, Via Celoria 26, 20133 Milan, Italy. ^[3] Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41100 Modena, Italy. ^[4] Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, 16132 Genova, Italy. ^[5] Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Cagliari, Cittadella Universitaria, 09042 Monserrato, CA, Italy. ^[6]

关键词 1-Aryl-4,6-diamino-1,2-dihydrotriazine derivatives Anti-RSV activity Anti-influenza A and B viruses activity Host (human) DHFR inhibition