首页> Journal of pharmaceutical sciences> Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

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第一作者： Soo-Jin,Kim

第一单位： Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, Yokohama, Japan; Drug Evaluation Group, R&D Center, CJ HealthCare, Icheon, Korea. Electronic address: soo-jin.kim@riken.jp.

作者： Soo-Jin,Kim ^[1] ; Kota,Toshimoto ^[2] ; Yoshiaki,Yao ^[3] ; Takashi,Yoshikado ^[2] ; Yuichi,Sugiyama ^[2]

作者单位： Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, Yokohama, Japan; Drug Evaluation Group, R&D Center, CJ HealthCare, Icheon, Korea. Electronic address: soo-jin.kim@riken.jp. ^[1] Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, Yokohama, Japan. ^[2] Analysis and Pharmacokinetics Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan. ^[3]

关键词 CYP enzymes clinical trial simulations drug interactions organic anion-transporting polypeptide transporters pharmacokinetics physiologically based pharmacokinetic modeling