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首页> International journal of cancer> Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.

Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.

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作者： Keqiang,Zhang ^[1] ; Jinhui,Wang ^[2] ; Tommy R,Tong ^[3] ; Xiwei,Wu ^[2] ; Rebecca,Nelson ^[4] ; Yate-Ching,Yuan ^[5] ; Theresa,Reno ^[1] ; Zheng,Liu ^[4] ; Xinwei,Yun ^[1] ; Jae Y,Kim ^[1] ; Ravi,Salgia ^[6] ; Dan J,Raz ^[1]

作者单位： Division of Thoracic Surgery, City of Hope National Medical Center, Duarte, CA. ^[1] The Integrative Genomics Core Lab of Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA. ^[2] Department of Pathology, City of Hope National Medical Center, Duarte, CA. ^[3] Division of Biostatistics, City of Hope National Medical Center, Duarte, CA. ^[4] The Bioinformatics Core lab of Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA. ^[5] Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA. ^[6]

关键词 H2B monoubiquitination RNF20 differentiation global transcriptional profiling lung adenocarcinoma malignancy

主题词腺癌(Adenocarcinoma);细胞凋亡(Apoptosis);细胞分化(Cell Differentiation);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);疾病恶化(Disease Progression);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲低技术(Gene Knockdown Techniques);基因调控网络(Gene Regulatory Networks);组蛋白类(Histones);人类(Humans);肺肿瘤(Lung Neoplasms);信号传导(Signal Transduction);存活率分析(Survival Analysis);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination)

DOI 10.1002/ijc.30769

PMID 28481029

发布时间 2019-02-21

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International journal of cancer

International journal of cancer

2017年141卷4期

766-777页

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