首页> Journal of medicinal chemistry> Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

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第一作者： William,McCoull

第一单位： IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K.

作者： William,McCoull ^[1] ; Roman D,Abrams ^[2] ; Erica,Anderson ^[3] ; Kevin,Blades ^[2] ; Peter,Barton ^[1] ; Matthew,Box ^[2] ; Jonathan,Burgess ^[2] ; Kate,Byth ^[3] ; Qing,Cao ^[3] ; Claudio,Chuaqui ^[3] ; Rodrigo J,Carbajo ^[1] ; Tony,Cheung ^[3] ; Erin,Code ^[3] ; Andrew D,Ferguson ^[3] ; Shaun,Fillery ^[1] ; Nathan O,Fuller ^[3] ; Eric,Gangl ^[3] ; Ning,Gao ^[3] ; Matthew,Grist ^[2] ; David,Hargreaves ^[1] ; Martin R,Howard ^[1] ; Jun,Hu ^[3] ; Paul D,Kemmitt ^[1] ; Jennifer E,Nelson ^[2] ; Nichole,O'Connell ^[3] ; D Bryan,Prince ^[3] ; Piotr,Raubo ^[1] ; Philip B,Rawlins ^[1] ; Graeme R,Robb ^[1] ; Junjie,Shi ^[4] ; Michael J,Waring ^[2] ; David,Whittaker ^[2] ; Marta,Wylot ^[1] ; Xiahui,Zhu ^[3]

作者单位： IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K. ^[1] IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K. ^[2] IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States. ^[3] Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China. ^[4]