Common sequence variants affect molecular function more than rare variants?

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第一作者： Yannick,Mahlich

第一单位： Computational Biology & Bioinformatics - i12, Informatics, Technical University of Munich (TUM), Boltzmannstrasse 3, 85748, Garching/Munich, Germany. ymahlich@bromberglab.org.

作者： Yannick,Mahlich ^[1] ; Jonas,Reeb ^[2] ; Maximilian,Hecht ^[3] ; Maria,Schelling ^[4] ; Tjaart Andries Petrus,De Beer ^[5] ; Yana,Bromberg ^[6] ; Burkhard,Rost ^[5]

作者单位： Computational Biology & Bioinformatics - i12, Informatics, Technical University of Munich (TUM), Boltzmannstrasse 3, 85748, Garching/Munich, Germany. ymahlich@bromberglab.org. ^[1] Department of Biochemistry and Microbiology, Rutgers University, 76 Lipman Dr, New Brunswick, NJ, 08901, USA. ymahlich@bromberglab.org. ^[2] TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), Technische Universität München, 85748, Garching/Munich, Germany. ymahlich@bromberglab.org. ^[3] Institute of Advanced Study (TUM-IAS), Lichtenbergstr. 2a, 85748, Garching/Munich, Germany. ymahlich@bromberglab.org. ^[4] Computational Biology & Bioinformatics - i12, Informatics, Technical University of Munich (TUM), Boltzmannstrasse 3, 85748, Garching/Munich, Germany. ^[5] TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), Technische Universität München, 85748, Garching/Munich, Germany. ^[6] European Molecular Biology Laboratories, European Bioinformatics Institute (EMBL-EBI), Welcome Trust Genomes Campus, Cambridge, Cambridgeshire, UK. ^[7] Department of Biochemistry and Microbiology, Rutgers University, 76 Lipman Dr, New Brunswick, NJ, 08901, USA. ^[8] Institute of Advanced Study (TUM-IAS), Lichtenbergstr. 2a, 85748, Garching/Munich, Germany. ^[9] Institute for Food and Plant Sciences WZW-Weihenstephan, Alte Akademie 8, Freising, Germany. ^[10]

主题词遗传变异(Genetic Variation);人类(Humans);突变(Mutation);蛋白质组(Proteome);软件(Software)

DOI 10.1038/s41598-017-01054-2

PMID 28487536

发布时间 2018-12-11

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