TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.

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第一作者： Maria Cristina,Marrone

第一单位： European Brain Research Institute-Fondazione Rita Levi Montalcini, 00143 Rome, Italy.

作者： Maria Cristina,Marrone ^[1] ; Annunziato,Morabito ^[2] ; Michela,Giustizieri ^[1] ; Valerio,Chiurchiù ^[3] ; Alessandro,Leuti ^[1] ; Marzia,Mattioli ^[2] ; Sara,Marinelli ^[2] ; Loredana,Riganti ^[4] ; Marta,Lombardi ^[2] ; Emanuele,Murana ^[1] ; Antonio,Totaro ^[2] ; Daniele,Piomelli ^[1] ; Davide,Ragozzino ^[5] ; Sergio,Oddi ^[6] ; Mauro,Maccarrone ^[7] ; Claudia,Verderio ^[8] ; Silvia,Marinelli ^[2]

作者单位： European Brain Research Institute-Fondazione Rita Levi Montalcini, 00143 Rome, Italy. ^[1] IRCCS Fondazione Santa Lucia, 00143 Rome, Italy. ^[2] Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rome 00185, Italy. ^[3] Department of Medicine, Campus Bio-Medico University of Rome, Rome 00128, Italy. ^[4] CNR-National Research Council, Institute of Cell Biology and Neurobiology, 00143 Rome, Italy. ^[5] CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milan, Italy. ^[6] IRCCS Humanitas, via Manzoni 56, 20089 Rozzano, Italy. ^[7] Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome 00185, Italy. ^[8] Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, I-16163 Genova, Italy. ^[9] IRCCS Neuromed, Via Atinese, Pozzilli 86077, Italy. ^[10] Faculty of Veterinary Medicine, University of Teramo, Teramo 64100, Italy. ^[11]

主题词动物(Animals);细胞源性微粒(Cell-Derived Microparticles);脑炎(Encephalitis);兴奋性突触后电位(Excitatory Postsynaptic Potentials);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);小神经胶质细胞(Microglia);神经痛(Neuralgia);神经元(Neurons);突触传递(Synaptic Transmission);TRPV阳离子通道(TRPV Cation Channels)

DOI 10.1038/ncomms15292

PMID 28489079

发布时间 2018-11-26

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Nature communications

2017年8卷

15292页

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TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.

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TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.

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