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An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®.

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第一作者： Zsuzsanna,Varga

第一单位： Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland. zsuzsanna.varga@usz.ch.

作者： Zsuzsanna,Varga ^[1] ; Annette,Lebeau ^[2] ; Hong,Bu ^[3] ; Arndt,Hartmann ^[4] ; Frederique,Penault-Llorca ^[5] ; Elena,Guerini-Rocco ^[6] ; Peter,Schraml ^[7] ; Fraser,Symmans ^[8] ; Robert,Stoehr ^[4] ; Xiaodong,Teng ^[9] ; Andreas,Turzynski ^[2] ; Reinhard,von Wasielewski ^[10] ; Claudia,Gürtler ^[11] ; Mark,Laible ^[11] ; Kornelia,Schlombs ^[11] ; Heikki,Joensuu ^[12] ; Thomas,Keller ^[13] ; Peter,Sinn ^[14] ; Ugur,Sahin ^[11] ; John,Bartlett ^[15] ; Giuseppe,Viale ^[6]

作者单位： Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland. zsuzsanna.varga@usz.ch. ^[1] Private Group Practice for Pathology and PathoPlan GbR, Lübeck, Germany. ^[2] Department of Pathology and Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, China. ^[3] Institute of Pathology, University Erlangen-Nürnberg, Erlangen, Germany. ^[4] Centre Jean Perrin, Centre regional de Lutte contre le cancer d'Auvergne, Clermont-Ferrand, France. ^[5] European Institute of Oncology, University of Milan, Milan, Italy. ^[6] Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland. ^[7] University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[8] Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. ^[9] Institute of Pathology, Klinikum Region Hannover, Hannover, Germany. ^[10] BioNTech Diagnostics GmbH, Mainz, Germany. ^[11] Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. ^[12] ACOMED Statistik, Leipzig, Germany. ^[13] Department of Pathology, Heidelberg University Hospital, Heidelberg, Germany. ^[14] Transformative Pathology, Ontario Institute for Cancer Research (OICR), Toronto, ON, Canada. ^[15]

关键词 Breast cancer ERBB2 ESR1 FFPE MKI67 MammaTyper PGR RT-qPCR Reproducibility