Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study.

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第一作者： Santiago,Rojas

第一单位： 1 Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.

作者： Santiago,Rojas ^[1] ; Anna,Brugulat-Serrat ^[2] ; Nuria,Bargalló ^[1] ; Carolina,Minguillón ^[3] ; Alan,Tucholka ^[4] ; Carles,Falcon ^[1] ; Andreia,Carvalho ^[1] ; Sebastian,Morán ^[1] ; Manel,Esteller ^[5] ; Nina,Gramunt ^[1] ; Karine,Fauria ^[6] ; Jordi,Camí ^[7] ; José L,Molinuevo ^[7] ; Juan D,Gispert ^[8]

作者单位： 1 Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain. ^[1] 2 Faculty of Medicine, Department of Morphological Sciences, Unit of Human Anatomy and Embryology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. ^[2] 3 Magnetic Resonance Imaging Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. ^[3] 4 Centre Mèdic Diagnòstic Alomar, Barcelona, Spain. ^[4] 5 Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain. ^[5] 6 MRC Center for Developmental Neurobiology, King's College London, London, UK. ^[6] 7 Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. ^[7] 8 Department of Physiological Sciences II, School of Medicine, University of Barcelona (UB), Barcelona, Spain. ^[8] 9 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ^[9] 10 Universitat Pompeu Fabra, Barcelona, Spain. ^[10] 11 Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. ^[11]

关键词 Alzheimer’s disease Apolipoprotein E cerebrovascular magnetic resonance imaging risk factors small vessel disease