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Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.

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第一作者： Angel,Garcia-Diaz

第一单位： Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Electronic address: agdiaz@ipb.csic.es.

作者： Angel,Garcia-Diaz ^[1] ; Daniel Sanghoon,Shin ^[2] ; Blanca Homet,Moreno ^[3] ; Justin,Saco ^[2] ; Helena,Escuin-Ordinas ^[2] ; Gabriel Abril,Rodriguez ^[2] ; Jesse M,Zaretsky ^[2] ; Lu,Sun ^[4] ; Willy,Hugo ^[4] ; Xiaoyan,Wang ^[5] ; Giulia,Parisi ^[2] ; Cristina Puig,Saus ^[2] ; Davis Y,Torrejon ^[2] ; Thomas G,Graeber ^[6] ; Begonya,Comin-Anduix ^[7] ; Siwen,Hu-Lieskovan ^[2] ; Robert,Damoiseaux ^[8] ; Roger S,Lo ^[9] ; Antoni,Ribas ^[10]

作者单位： Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Electronic address: agdiaz@ipb.csic.es. ^[1] Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. ^[2] Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Division of Translational Oncology, Carlos III Health Institute, 28029 Madrid, Spain. ^[3] Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA. ^[4] Statistics Core, Department of Medicine, UCLA, Los Angeles, CA 90095, USA. ^[5] Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA. ^[6] Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, CA 90095, USA. ^[7] Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; California NanoSystems Institute, UCLA, Los Angeles, CA 90095, USA. ^[8] Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA. ^[9] Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, CA 90095, USA. Electronic address: aribas@mednet.ucla.edu. ^[10]

关键词 IRF1 JAK-STATs PD-1 PD-L1 PD-L2 immunotherapy interferon receptor signaling pathways melanoma

医学主题词细胞系, 肿瘤(Cell Line, Tumor);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);干扰素调节因子1(Interferon Regulatory Factor-1);干扰素β(Interferon-beta);干扰素γ(Interferon-gamma);Janus激酶1(Janus Kinase 1);Janus激酶2(Janus Kinase 2);黑色素瘤(Melanoma);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);STAT转录因子类(STAT Transcription Factors);信号传导(Signal Transduction);转录激活(Transcriptional Activation);增量调节(Up-Regulation)

DOI 10.1016/j.celrep.2017.04.031

PMID 28494868

发布时间 2024-07-15

基金项目

R35 CA197633/CA/NCI NIH HHS/United States T32 CA009297/CA/NCI NIH HHS/United States P01 CA168585/CA/NCI NIH HHS/United States T32 AR058921/AR/NIAMS NIH HHS/United States P30 CA016042/CA/NCI NIH HHS/United States P30 AI028697/AI/NIAID NIH HHS/United States P30 DK041301/DK/NIDDK NIH HHS/United States T32 CA009120/CA/NCI NIH HHS/United States

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