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Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.

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第一作者： Joana,Neves

第一单位： Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Im Neuenheimer Feld 350, D-69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, D-69120 Heidelberg, Germany; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4050-343 Porto, Portugal; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, D-69120 Heidelberg, Germany.

作者： Joana,Neves ^[1] ; Dominik,Leitz ^[2] ; Simone,Kraut ^[3] ; Christina,Brandenberger ^[4] ; Raman,Agrawal ^[2] ; Norbert,Weissmann ^[3] ; Christian,Mühlfeld ^[4] ; Marcus A,Mall ^[5] ; Sandro,Altamura ^[6] ; Martina U,Muckenthaler ^[7]

作者单位： Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Im Neuenheimer Feld 350, D-69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, D-69120 Heidelberg, Germany; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4050-343 Porto, Portugal; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, D-69120 Heidelberg, Germany. ^[1] Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, D-69120 Heidelberg, Germany; Department of Translational Pulmonology, University of Heidelberg, D-69120 Heidelberg, Germany. ^[2] Justus-Liebig University of Giessen (JLUG), Excellence Cluster Cardiopulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Germany. ^[3] Institute of Functional and Applied Anatomy, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, D-30625 Hannover, Germany. ^[4] Molecular Medicine Partnership Unit, D-69120 Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, D-69120 Heidelberg, Germany; Department of Translational Pulmonology, University of Heidelberg, D-69120 Heidelberg, Germany. ^[5] Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Im Neuenheimer Feld 350, D-69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, D-69120 Heidelberg, Germany. ^[6] Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Im Neuenheimer Feld 350, D-69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, D-69120 Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, D-69120 Heidelberg, Germany. Electronic address: martina.muckenthaler@med.uni-heidelberg.de. ^[7]

关键词 Ferroportin Hepcidin resistance Hereditary hemochromatosis Iron Overload Restrictive lung disease