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Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity.

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第一作者： Pornvichai,Temboot

第一单位： Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.

作者： Pornvichai,Temboot ^[1] ; Ronald F S,Lee ^[2] ; Laure,Menin ^[2] ; Luc,Patiny ^[2] ; Paul J,Dyson ^[2] ; Adisorn,Ratanaphan ^[3]

作者单位： Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand. ^[1] Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland. ^[2] Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand. Electronic address: adisorn.r@psu.ac.th. ^[3]

关键词 BRCA1 BRCA1 dysfunction Breast cancer E3 ubiquitin ligase Ruthenium complexes Zinc finger protein