Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

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作者： Nadinath B,Nillegoda ^[1] ; Antonia,Stank ^[2] ; Duccio,Malinverni ^[3] ; Niels,Alberts ^[4] ; Anna,Szlachcic ^[5] ; Alessandro,Barducci ^[1] ; Paolo,De Los Rios ^[1] ; Rebecca C,Wade ^[6] ; Bernd,Bukau ^[7]

作者单位： Center for Molecular Biology (ZMBH), Heidelberg University, Heidelberg, Germany. ^[1] DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[2] Heidelberg Institute for Theoretical Studies, Heidelberg, Germany. ^[3] Heidelberg Graduate School of Mathematical and Computational Methods for the Sciences, University of Heidelberg, Heidelberg, Germany. ^[4] Laboratory of Statistical Biophysics, School of Basic Sciences, Institute of Physics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. ^[5] Inserm, U1054, Montpellier, France. ^[6] CNRS, UMR 5048, Centre de Biochimie Structurale, Université de Montpellier, Montpellier, France. ^[7] Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. ^[8] Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany. ^[9]

关键词 E. coli Hsp40 Hsp70 J-protein S. cerevisiae biochemistry biophysics chaperone evolution protein disaggregation and refolding structural biology