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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

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第一作者： Xianjun,Zhang

第一单位： iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.;Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.;University of Chinese Academy of Sciences, Beijing 100049, China.

作者： Xianjun,Zhang ^[1] ; Fei,Zhao ^[2] ; Yiran,Wu ^[2] ; Jun,Yang ^[3] ; Gye Won,Han ^[4] ; Suwen,Zhao ^[5] ; Andrii,Ishchenko ^[4] ; Lintao,Ye ^[6] ; Xi,Lin ^[1] ; Kang,Ding ^[7] ; Venkatasubramanian,Dharmarajan ^[8] ; Patrick R,Griffin ^[8] ; Cornelius,Gati ^[9] ; Garrett,Nelson ^[10] ; Mark S,Hunter ^[11] ; Michael A,Hanson ^[12] ; Vadim,Cherezov ^[4] ; Raymond C,Stevens ^[5] ; Wenfu,Tan ^[3] ; Houchao,Tao ^[2] ; Fei,Xu ^[5]

作者单位： iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.;Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.;University of Chinese Academy of Sciences, Beijing 100049, China. ^[1] iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China. ^[2] Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China. ^[3] Departments of Chemistry, Biological Sciences and Physics &Astronomy, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA. ^[4] iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. ^[5] iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.;Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 555 Zuchongzhi Lu, Building 3, Room 426, Shanghai 201203, China. ^[6] iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.;Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. ^[7] Department of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, USA. ^[8] Medical Research Council, Laboratory of Molecular Biology, Cambridge, Biomedical Campus, Francis Crick Avenue, Cambridge CB2 OQH, UK. ^[9] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA. ^[10] Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA. ^[11] GPCR Consortium, San Marcos, California 92078, USA. ^[12]