Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis.-论文-万方医学网

作者： Miao,Xian ^[1] ; Handi,Cao ^[1] ; Ji,Cao ^[1] ; Xuejing,Shao ^[1] ; Difeng,Zhu ^[1] ; Ning,Zhang ^[2] ; Ping,Huang ^[3] ; Weixu,Li ^[4] ; Bo,Yang ^[3] ; Meidan,Ying ^[1] ; Qiaojun,He ^[1]

作者单位： Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. ^[1] Center for Drug Safety Evaluation and Research of Zhejiang University, Zhejiang University, Hangzhou, 310058, China. ^[2] Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, 310009, China. ^[3] Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, 310000, China. ^[4]

主题词转录激活因子4(Activating Transcription Factor 4);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);骨肿瘤(Bone Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);多柔比星(Doxorubicin);真核细胞起始因子2(Eukaryotic Initiation Factor-2);流式细胞术(Flow Cytometry);人类(Humans);小鼠(Mice);小鼠, 裸(Mice, Nude);骨肉瘤(Osteosarcoma);活性氧(Reactive Oxygen Species);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);转录因子CHOP(Transcription Factor CHOP);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1002/ijc.30792

PMID 28524233

发布时间 2018-02-16

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Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis.

International journal of cancer

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International journal of cancer

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Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis.

International journal of cancer

相似文献

International journal of cancer

相关期刊

检索历史清除