Novel amidino substituted benzimidazole and benzothiazole benzo[b]thieno-2-carboxamides exert strong antiproliferative and DNA binding properties.

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作者： Maja,Cindrić ^[1] ; Samy,Jambon ^[2] ; Anja,Harej ^[3] ; Sabine,Depauw ^[2] ; Marie-Hélène,David-Cordonnier ^[4] ; Sandra,Kraljević Pavelić ^[3] ; Grace,Karminski-Zamola ^[1] ; Marijana,Hranjec ^[5]

作者单位： Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, P. O. Box 177, HR-10000 Zagreb, Croatia. ^[1] INSERM UMR-S1172, Jean-Pierre Aubert Research Centre (JPARC), Université de Lille, Hospital Centre of Lille (CHU), Institut pour la Recherche sur le Cancer de Lille (IRCL), Place de Verdun, F-59045 Lille cedex, France. ^[2] Department of Biotechnology, Centre for High-throughput technologies, University of Rijeka, Radmile Matejčić 2, HR-51000 Rijeka, Croatia. ^[3] INSERM UMR-S1172, Jean-Pierre Aubert Research Centre (JPARC), Université de Lille, Hospital Centre of Lille (CHU), Institut pour la Recherche sur le Cancer de Lille (IRCL), Place de Verdun, F-59045 Lille cedex, France. Electronic address: marie-helene.david@inserm.fr. ^[4] Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, P. O. Box 177, HR-10000 Zagreb, Croatia. Electronic address: mhranjec@fkit.hr. ^[5]

关键词 Amidines Antiproliferative activity Benzimidazoles Benzothiazoles DNA binding Topoisomerase poisoning benzo[b]thieno-2-carboxamides