Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia.

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第一作者： Manoj K,Kashyap

第一单位： Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA, 92093-0820, USA.

作者： Manoj K,Kashyap ^[1] ; Carlos I,Amaya-Chanaga ^[1] ; Deepak,Kumar ^[1] ; Brett,Simmons ^[2] ; Nanni,Huser ^[2] ; Yin,Gu ^[2] ; Max,Hallin ^[2] ; Kevin,Lindquist ^[3] ; Rolla,Yafawi ^[4] ; Michael Y,Choi ^[5] ; Ale-Ali,Amine ^[1] ; Laura Z,Rassenti ^[6] ; Cathy,Zhang ^[1] ; Shu-Hui,Liu ^[1] ; Tod,Smeal ^[6] ; Valeria R,Fantin ^[2] ; Thomas J,Kipps ^[4] ; Flavia,Pernasetti ^[2] ; Januario E,Castro ^[7]

作者单位： Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA, 92093-0820, USA. ^[1] Oncology Research & Development, Pfizer Worldwide Research & Development, 10646 Science Center Drive, San Diego, CA, 92121, USA. ^[2] Present Address: Mirati Therapeutics, San Diego, CA, USA. ^[3] Oncology Research & Development-Rinat Biotechnology Unit, Pfizer Worldwide Research & Development, South San Francisco, CA, USA. ^[4] Drug Safety Research & Development, Pfizer Worldwide Research & Development, La Jolla, CA, USA. ^[5] CLL Research Consortium, and Department of Medicine, University of California San Diego, La Jolla, CA, USA. ^[6] Present Address: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. ^[7] Present Address: ORIC Pharmaceuticals, South San Francisco, CA, USA. ^[8] Oncology Research & Development, Pfizer Worldwide Research & Development, 10646 Science Center Drive, San Diego, CA, 92121, USA. flavia.pernasetti@pfizer.com. ^[9] Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA, 92093-0820, USA. jecastro@ucsd.edu. ^[10] CLL Research Consortium, and Department of Medicine, University of California San Diego, La Jolla, CA, USA. jecastro@ucsd.edu. ^[11]

关键词 ADCC CDC CXCL12 CXCR4 Cell death Chemokine Chronic lymphocytic leukemia PF-06747143 Reactive oxygen species