Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.

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作者： Rachel H,Rose ^[1] ; David B,Turner ^[2] ; Sibylle,Neuhoff ^[2] ; Masoud,Jamei ^[2]

作者单位： Simcyp (a Certara Company), Blades Enterprise Centre, John Street, S2 4SU, Sheffield, UK. Rachel.rose@certara.com. ^[1] Simcyp (a Certara Company), Blades Enterprise Centre, John Street, S2 4SU, Sheffield, UK. ^[2]

关键词 PBPK food effect high extraction ratio pharmacokinetics splanchnic blood flow

主题词投药, 口服(Administration, Oral);曲线下面积(Area Under Curve);食品药物相互作用(Food-Drug Interactions);人类(Humans);模型, 生物学(Models, Biological);药代动力学(Pharmacokinetics);饭后期间(Postprandial Period);内脏循环(Splanchnic Circulation)

DOI 10.1208/s12248-017-0099-z

PMID 28526963

发布时间 2018-11-13

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The AAPS journal

2017年19卷4期

1205-1217页

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Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.

The AAPS journal

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The AAPS journal

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Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.

The AAPS journal

相似文献

The AAPS journal

相关期刊

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