首页> Bioorganic & medicinal chemistry> The impact of the halogen bonding on D2 and 5-HT1A/5-HT7 receptor activity of azinesulfonamides of 4-[(2-ethyl)piperidinyl-1-yl]phenylpiperazines with antipsychotic and antidepressant properties.

The impact of the halogen bonding on D2 and 5-HT1A/5-HT7 receptor activity of azinesulfonamides of 4-[(2-ethyl)piperidinyl-1-yl]phenylpiperazines with antipsychotic and antidepressant properties.

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第一作者： Anna,Partyka

第一单位： Department of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.

作者： Anna,Partyka ^[1] ; Rafał,Kurczab ^[2] ; Vittorio,Canale ^[3] ; Grzegorz,Satała ^[2] ; Krzysztof,Marciniec ^[4] ; Agnieszka,Pasierb ^[3] ; Magdalena,Jastrzębska-Więsek ^[1] ; Maciej,Pawłowski ^[3] ; Anna,Wesołowska ^[1] ; Andrzej J,Bojarski ^[2] ; Paweł,Zajdel ^[5]

作者单位： Department of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland. ^[1] Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, 12 Smętna Street, 31-343 Krakow, Poland. ^[2] Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland. ^[3] Department of Organic Chemistry, Medical University of Silesia, 4 Jagiellońska Street, 41-200 Sosnowiec, Poland. ^[4] Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland. Electronic address: pawel.zajdel@uj.edu.pl. ^[5]

关键词 Azinesulfonamides Depression Halogen bonding Multi-target ligands Multimodal dopamine/serotonin ligands Schizophrenia Semi-rigid long-chain arylpiperazines