换一批
换一批Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.
作者：
主题词
别构调节(Allosteric Regulation);氨基吡啶类(Aminopyridines);动物(Animals);药物评价, 临床前(Drug Evaluation, Preclinical);HEK293细胞(HEK293 Cells);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);成束猴(Macaca fascicularis);男(雄)性(Male);小鼠, 近交系(Mice, Inbred Strains);吡啶羧酸类(Picolinic Acids);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);构效关系(Structure-Activity Relationship);组织分布(Tissue Distribution)
DOI
10.1021/acs.jmedchem.7b00410
PMID
28530802
发布时间
2019-06-10
- 浏览11
Journal of medicinal chemistry
5072-5085页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
