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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.

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作者单位: Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114. [1] Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom. [2] Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom. [3] Institute of Molecular Genetics of Montpellier, F-34293 Montpellier, France. [4] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4. [5] Department of Developmental, Molecular and Chemical Biology, Tufts University, Boston, MA 02111. [6] Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany. [7] Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710. [8] Department of Neurobiology, Duke University Medical Center, Durham, NC 27710. [9] Department of Chemistry, Boston College, Chestnut Hill, MA 02467. [10] Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom. [11] Department of Medicinal Chemistry, Aurigene Discovery Technologies Limited, Bangalore 560 100, India. [12] Buck Institute for Research on Aging, Novato, CA 94945. [13] Targanox, Cambridge Research Laboratories, Cambridge, MA 02139. [14] Department of Biological Chemistry, University of California, Irvine, CA 92697. [15] Department of Neurobiology and Behavior, University of California, Irvine, CA 92697. [16] Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697. [17] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205. [18] Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205. [19] Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114; akazantsev47@gmail.com. [20]
DOI 10.1073/pnas.1614943114
PMID 28533375
发布时间 2024-03-06
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Proceedings of the National Academy of Sciences of the United States of America

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