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Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression.

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第一作者： F,Dumetz

第一单位： Molecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.

作者： F,Dumetz ^[1] ; H,Imamura ^[1] ; M,Sanders ^[2] ; V,Seblova ^[3] ; J,Myskova ^[3] ; P,Pescher ^[4] ; M,Vanaerschot ^[1] ; C J,Meehan ^[5] ; B,Cuypers ^[6] ; G,De Muylder ^[1] ; G F,Späth ^[4] ; G,Bussotti ^[4] ; J R,Vermeesch ^[7] ; M,Berriman ^[2] ; J A,Cotton ^[2] ; P,Volf ^[3] ; J C,Dujardin ^[8] ; M A,Domagalska ^[9]

作者单位： Molecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium. ^[1] Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom. ^[2] Charles University, Prague, Czech Republic. ^[3] Unité de Parasitologie Moléculaire et Signalisation, INSERM U1201, Institut Pasteur, Paris, France. ^[4] Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium. ^[5] Molecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.;Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium. ^[6] Molecular Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven, Leuven, Belgium. ^[7] Molecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium jcdujardin@itg.be mdomagalska@itg.be.;Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. ^[8] Molecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium jcdujardin@itg.be mdomagalska@itg.be. ^[9]

关键词 Leishmania aneuploidy gene dosage genomics life cycle