Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects.

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第一作者： Gemma,Hancock

第一单位： Oxford NIHR Biomedical Research Centre, Nufﬁeld Department of Medicine, University of Oxford, Oxford, UK.

作者： Gemma,Hancock ^[1] ; Sara,Morón-López ^[2] ; Jakub,Kopycinski ^[1] ; Maria C,Puertas ^[2] ; Eleni,Giannoulatou ^[3] ; Annie,Rose ^[4] ; Maria,Salgado ^[1] ; Emma-Jo,Hayton ^[2] ; Alison,Crook ^[1] ; Catharine,Morgan ^[1] ; Brian,Angus ^[5] ; Fabian,Chen ^[1] ; Hongbing,Yang ^[6] ; Javier,Martinez-Picado ^[1] ; Tomas,Hanke ^[2] ; Lucy,Dorrell ^[7]

作者单位： Oxford NIHR Biomedical Research Centre, Nufﬁeld Department of Medicine, University of Oxford, Oxford, UK. ^[1] AIDS Research Institute IrsiCaixa, Institut d'Investigació en Cièncias de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain. ^[2] Computational Genomics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, Australia. ^[3] University of New South Wales, Australia. ^[4] Oxfordshire Sexual Health Service, Oxford University Hospitals NHS Trust, Oxford, UK. ^[5] The Florey: Sexual Health, Royal Berkshire NHS Foundation Trust, Reading, UK. ^[6] Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain. ^[7] Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ^[8]

关键词 MVA T cells conservation human immunodeficiency virus immunogen design phase I trial therapeutic vaccine viral inhibition assay