CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.

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作者： Jiyeon,Kim ^[1] ; Zeping,Hu ^[1] ; Ling,Cai ^[1] ; Kailong,Li ^[1] ; Eunhee,Choi ^[2] ; Brandon,Faubert ^[1] ; Divya,Bezwada ^[1] ; Jaime,Rodriguez-Canales ^[3] ; Pamela,Villalobos ^[3] ; Yu-Fen,Lin ^[4] ; Min,Ni ^[1] ; Kenneth E,Huffman ^[5] ; Luc,Girard ^[5] ; Lauren A,Byers ^[6] ; Keziban,Unsal-Kacmaz ^[7] ; Christopher G,Peña ^[8] ; John V,Heymach ^[6] ; Els,Wauters ^[9] ; Johan,Vansteenkiste ^[9] ; Diego H,Castrillon ^[8] ; Benjamin P C,Chen ^[4] ; Ignacio,Wistuba ^[3] ; Diether,Lambrechts ^[10] ; Jian,Xu ^[11] ; John D,Minna ^[1] ; Ralph J,DeBerardinis ^[5]

作者单位： Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[1] Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[2] Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA. ^[3] Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[4] Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[5] Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas 77030, USA. ^[6] Oncology Research Unit, Pfizer, 401 North Middletown Road, Pearl River, New York 10965, USA. ^[7] Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[8] Respiratory Division, University of Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. ^[9] Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000 Leuven, Belgium. ^[10] VIB Center for Cancer Biology, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000 Leuven, Belgium. ^[11] Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[12] McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas 75390, USA. ^[13]