Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.

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第一作者： Boris,Julg

第一单位： Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.;Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

作者： Boris,Julg ^[1] ; Amarendra,Pegu ^[2] ; Peter,Abbink ^[3] ; Jinyan,Liu ^[3] ; Amanda,Brinkman ^[3] ; Katherine,Molloy ^[3] ; Shanell,Mojta ^[3] ; Abishek,Chandrashekar ^[3] ; Katherine,Callow ^[4] ; Keyun,Wang ^[2] ; Xuejun,Chen ^[2] ; Stephen D,Schmidt ^[2] ; Jinghe,Huang ^[5] ; Richard A,Koup ^[2] ; Michael S,Seaman ^[3] ; Brandon F,Keele ^[6] ; John R,Mascola ^[2] ; Mark,Connors ^[5] ; Dan H,Barouch ^[7]

作者单位： Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.;Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. ^[1] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[2] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. ^[3] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA. ^[4] Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[5] AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. ^[6] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA dbarouch@bidmc.harvard.edu.;Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. ^[7]

关键词 antiviral activity in vivo autologous immune responses bnAbs broadly neutralizing antibodies cellular reservoir effect on tissue viral reservoir immunotherapy